Metabolic Inflammation

Annual Women's Health Section

A malfunctioning metabolism can cause inflammation and hinder weight loss.

Understanding Metabolic Inflammation

Metabolic inflammation, or metaflammation, occurs when excess fat tissue and insulin stimulate the immune and inflammatory systems and result in chronic, low-grade inflammation. This metabolic dysfunction increases insulin resistance, making weight loss difficult and putting the individual at risk of developing type 2 diabetes. Metaflammation can also impact tissues in the liver and pancreas and increase the risk of heart disease due to its effects on the cardiovascular system.

Causes and Symptoms

Metaflammation is most commonly linked to weight gain and obesity. Excess nutrient intake causes this metabolic response, and dietary factors such as saturated fatty acids and some sugars may also contribute to the inflammation.

woman measuring her waist line

Because metaflammation is a chronic, low-grade reaction, it will not have the same symptoms as acute inflammation triggered by the immune system. Along with difficulty or inability to lose weight, symptoms include fatigue and signs of insulin resistance such as increased hunger and thirst, blurred vision, and frequent urination.

Treatment and Outlook

In addition to a healthy lifestyle that involves regular exercise and a nutritious diet, innovative formulas can help women suffering from metaflammation achieve their weight loss goals. The medication ingredients phentermine and topiramate are clinically proven to result in up to 11% weight loss when used together, and as understanding of metaflammation grows, low dose naltrexone is also being added to formulas to fight inflammation.

If you are struggling to fight the pro-inflammatory aspect of carrying extra pounds, consult with your doctor to determine the best path forward. With proper treatment, you can reduce the risk of serious complications and enjoy a better quality of life.

An Expert Weighs In

“Metaflammation describes the metabolic inflammation that usually involves adipose tissue (fat) and insulin. It can also involve sex hormones such as estrogen and testosterone and adrenal hormones such as cortisol. Fat stimulates the immune and inflammatory system! It speaks through chemical messengers ultimately resulting in inflammation, which leads to insulin resistance and cardiovascular dysfunction. Is this the type of inflammation that you take ibuprofen for? Nope! Ibuprofen is not a precision medicine approach to inflammation, however low-dose naltrexone (LDN) could be.”

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